The original building of Spolchemie Headquarters was built in the Neo-Gothic style by the architect Robert Langs in 1895. The most impressive part of the building is the main staircase hall with a large wall painting by Josef Reiner dating back to 1900. On the first floor there is a meeting room of the Board of Directors, boasting a preserved Neo-Gothic interior. The original administrative building of the Association stopped serving its purpose in 1931 and it was rebuilt into research and testing laboratories, since 1952 it has housed the Research Institute of Anorganic Chemistry.

The new adjacent administrative building was built in 1929-1930. At the time it was completed this 9 storey-high building was one of the highest constructions in Czechoslovakia. A paternoster lift has been preserved in the building.